Formulate and Evaluate, Fast Dissolving thin Film of Metoprolol Succinate

Objective: Metoprolol succinate, which is used to treat cardiovascular disorders, a strong beta-1 adrenoreceptor blocker with cardio-selective effect but heavily metabolised in the liver during first pass. Our goal minimise hypertension by creating film of metoprolol succinate that dissolves quickly.
 Methods: films dissolve mouth were made utilising solvent casting technique. HPMC E5 was as film-forming agent, PEG400 plasticizer, and honey included film-modifying agent final formulation. E15 (X1) (X2) concentrations independent variables, whereas disintegration time (DT), tensile strength (TS), % cumulative drug release (CDR) dependent variables 32-full factorial design. Thickness, folding endurance, strength, time, among criteria assess manufactured films. Results showed both positively impacted DT TS while negatively impacting CDR.
 Results: The optimum formulation determined be one 58.0 ±1.01 seconds, an vitro 105.32± 1.55, 73.55 ± 1.37 g/cm2.
 Conclusion: Thus, employing method, fast-dissolving thin created effective taste masking prompt release.
 Keywords: Fast dissolving oral film, E5, Honey, Solvent